Selective anticancer copper(<scp>ii</scp>)-mixed ligand complexes: targeting of ROS and proteasomes
Journal
Metallomics
ISSN
1756-5901
Date Issued
2014
Author(s)
Chew Hee Ng
Siew Ming Kong
Yee Lian Tiong
Mohd Jamil Maah
Nurhazwani Sukram
Munirah Ahmad
Alan Soo Beng Khoo
DOI
10.1039/c3mt00276d
Abstract
The ternary copper(ii) complexes 1–4 exhibited anticancer selectivity, as evidenced by MTT assay, % apoptosis, cell cycle arrest, ROS induction and DNA DSBs. Proteasome of cancer cells are also inhibited.
