Synthesis and Characterization of Some New Spirothiadiazole Oxindoles and their Mannich Bases

<jats:sec>
<jats:title>Abstract:</jats:title>
<jats:p>A series of new spirothiadiazole oxindoles were synthesized by the reaction of 4-amino-5-
mercapto-3-[(1H-indol-3-yl)methyl]-1,2,4-triazole and isatin derivatives. The reaction of spiro [indole]
thiadiazoles with formaldehyde and piperidine afforded the corresponding Mannich bases. The structures
of newly synthesized compounds were characterized by IR, 1D-NMR, 2D-NMR, and LC/MS
spectral data.</jats:p>
</jats:sec>