Bee Chin AngHui Yin NamMuhammad Faiq AbdullahFarina MuhamadYen Bach Truong2025-08-062025-08-062024-11-0310.1002/marc.202400620https://dspace-cris.utar.edu.my/handle/123456789/11291This review explores core-shell scaffolds in bone tissue engineering, highlighting their osteoconductive and osteoinductive properties critical for bone growth and regeneration. Key design factors include material selection, porosity, mechanical strength, biodegradation kinetics, and bioactivity. Electrospun core-shell nanofibrous scaffolds demonstrate potential in delivering therapeutic agents and enhancing bone regeneration. Critical characterization techniques include structural, surface, chemical composition, mechanical, and degradation analyses. Scaling up production poses challenges, addressed by innovative electrospinning techniques. Future research focuses on regulatory and commercial considerations, while exploring advanced materials and fabrication methods to optimize scaffold performance for improved clinical outcomes. © 2024 Wiley-VCH GmbH.enbone defectcore-shellelectrospinningscaffoldAnimalsBiocompatible MaterialsBone and BonesBone RegenerationHumansPorosityTissue EngineeringTissue ScaffoldsBiodegradationCore shell nanoparticlesDegradationScaffoldsScaffolds (biology)Shells (structures)Tissue regenerationbiomaterialBone defectBone growthBone regenerationBone tissue engineeringClinical translationCore shellDesign factorsEngineering designOsteoconductive propertiesOsteoinductive propertiesanimalbonebone regenerationchemistryhumanporosityprocedurestissue engineeringtissue scaffoldBonetext::review