Yit-Lai Chowteh lai kuanLoh Huey ChyiLi Fang LimChin Chu YeeLoo Keat Wei2024-10-232024-10-232020-10-13https://doi.org/10.2174/1381612826666200614180958https://dspace-cris.utar.edu.my/handle/123456789/4394<jats:sec> <jats:title /> <jats:p>Stroke is the second leading cause of death and a major cause of disability worldwide. Both modifiable and non-modifiable risk factors can affect the occurrence of ischemic stroke at varying degrees. Among them, atherosclerosis has been well-recognized as one of the main culprits for the rising incidence of stroke-related mortality. Hence, the current review aimed to summarize the prominent role of lipid metabolism genes such as PCSK9, ApoB, ApoA5, ApoC3, ApoE, and ABCA1 in mediating ischemic stroke occurrence.</jats:p> </jats:sec>journal-article