Ying Ping Chang0000-0001-7663-1691Kwan Kit Woo2025-09-242025-09-2420259783031806995978303180700810.1007/978-3-031-80700-8_12https://dspace-cris.utar.edu.my/handle/123456789/11356In 2021, global sweet potato production hit 88.9 million metric tons, with China leading the pack, contributing 55% of the world’s total. Sweet potatoes are a highly adaptable crop, capable of thriving in marginal growing conditions with a wide production geography, short production cycles, and high yield potential. It is the most efficient staple food crop, with 14–26 metric tons per hectare yield and higher nutrient density than cereals. However, the cultivation and processing of sweet potatoes generate significant organic waste in the form of solid and liquid by-products, including peelings, trimmings, leaves, stems, and stalks. These by-products contain macronutrients such as carbohydrates, proteins, and bioactive compounds or phytochemicals such as phenolics, anthocyanins, and carotenoids that can be extracted or used in various downstream processes and products. This chapter reviews the valuable compounds found in sweet potato peels, leaves, stems, and stalks and methods for extracting bioactive compounds and other valuable ingredients. It also discusses the functional properties of the extract and bioactive compounds and their applications in food and non-food products and explores opportunities for their utilization for non-health-related purposes. Finally, the chapter provides research gaps for further investigation in the valorization of sweet potato by-products. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.enBioactiveLeavesPeelsPhytochemicalsSweet potatoDietary supplementsFruitsOilseedsTrimmingYeastBioactive compoundsBioactivesGrowing conditionsHigher yieldLeafMarginalsPeelPhytochemicalProduction cycleVitaminsbook-chapter