Zhen Yun SiewIsaac SeowXin Rui LimChen Zhe TangFadhilah Moh DjamilGhee Khang Ong0000-0002-0286-6428Leong Pooi PooiSiew Tung WongKenny Voon2025-09-122025-09-122025-05-2610.1007/s00705-025-06314-5https://dspace-cris.utar.edu.my/handle/123456789/11333Arboviruses are viruses that are transmitted by arthropods such as mosquitoes, ticks, and flies, and most of them are RNA viruses. Vector-borne transmission occurs when an infected arthropod bites a vertebrate host, allowing the virus to enter the bloodstream and initiate infection. Arboviruses are known to cause significant morbidity and mortality in mammals, and at least a hundred of them have been identified as human pathogens. In this review, we provide an updated overview of four prominent arboviruses that are present in Southeast Asia (SEA): dengue virus (DENV), Japanese encephalitis virus (JEV), Zika virus (ZIKV), and chikungunya virus (CHIKV). The epidemiology and pathogenesis of these viruses and the currently used methods for diagnosis, prevention, and treatment of arbovirus infections are discussed in detail. Finally, we summarise the concerns and future considerations for combating these dangerous pathogens.en-USJAPANESE ENCEPHALITIS-VIRUSTETRAVALENT DENGUE VACCINEZIKA VIRUSDOUBLE-BLINDCHIKUNGUNYA VIRUSIMMUNE-RESPONSEINFECTIONDIAGNOSISOUTBREAKSAFETYtext::review